Do not apply anything to the blisters without talking to his doctor first. If your baby develops a blistering rash from diarrhea, call his pediatrician immediately. A cool cloth soaked with clean water might also bring some relief to your baby. This might ease your baby's discomfort and will help keep the area clean. ![]() Squirt clean water on the blisters using a spray bottle and allow to air-dry. Your baby's pediatrician might also recommend an anti-fungal cream, an antibiotic cream or a mild steroid cream, depending on the type of blister or rash he has. A petroleum-based diaper rash cream might also help 3. A zinc-based diaper rash cream might help protect your baby's blisters by keeping moisture away from the skin 3. If your baby has diarrhea, change his diaper immediately after he has a bowel movement. The best treatment for diaper rash is to keep the area clean and dry 3.
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